Developments in antiviral drug design, discovery and development in 2004.
Identifieur interne : 004864 ( Main/Exploration ); précédent : 004863; suivant : 004865Developments in antiviral drug design, discovery and development in 2004.
Auteurs : Nicholas A. Meanwell [États-Unis] ; Makonen Belema ; David J. Carini ; Stanley V. D'Andrea ; John F. Kadow ; Mark Krystal ; B Narasimhulu Naidu ; Alicia Regueiro-Ren ; Paul M. Scola ; Sing-Yuen Sit ; Michael A. Walker ; Tao Wang ; Kap-Sun YeungSource :
- Current drug targets. Infectious disorders [ 1568-0053 ] ; 2005.
Descripteurs français
- KwdFr :
- Agents antiVIH (), Agents antiVIH (pharmacologie), Animaux, Antiviraux (), Antiviraux (pharmacologie), Conception de médicament, Données de séquences moléculaires, Essais cliniques comme sujet, Herpesviridae (), Humains, Inhibiteurs de l'intégrase du VIH (), Inhibiteurs de l'intégrase du VIH (pharmacologie), Inhibiteurs de la synthèse d'acide nucléique, Inhibiteurs de la transcriptase inverse (), Inhibiteurs de la transcriptase inverse (pharmacologie), Inhibiteurs de protéases (), Inhibiteurs de protéases (pharmacologie), Nucléosides (), Nucléosides (pharmacologie), Orthomyxoviridae (), Structure moléculaire, Séquence d'acides aminés, VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (), VIH-2 (Virus de l'Immunodéficience Humaine de type 2) (), Virus de l'hépatite (), Virus du SRAS (), Évaluation préclinique de médicament.
- MESH :
- pharmacologie : Agents antiVIH, Antiviraux, Inhibiteurs de l'intégrase du VIH, Inhibiteurs de la transcriptase inverse, Inhibiteurs de protéases, Nucléosides.
- Agents antiVIH, Animaux, Antiviraux, Conception de médicament, Données de séquences moléculaires, Essais cliniques comme sujet, Herpesviridae, Humains, Inhibiteurs de l'intégrase du VIH, Inhibiteurs de la synthèse d'acide nucléique, Inhibiteurs de la transcriptase inverse, Inhibiteurs de protéases, Nucléosides, Orthomyxoviridae, Structure moléculaire, Séquence d'acides aminés, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), VIH-2 (Virus de l'Immunodéficience Humaine de type 2), Virus de l'hépatite, Virus du SRAS, Évaluation préclinique de médicament.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Anti-HIV Agents (chemistry), Anti-HIV Agents (pharmacology), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Clinical Trials as Topic, Drug Design, Drug Evaluation, Preclinical, HIV Integrase Inhibitors (chemistry), HIV Integrase Inhibitors (pharmacology), HIV-1 (drug effects), HIV-2 (drug effects), Hepatitis Viruses (drug effects), Herpesviridae (drug effects), Humans, Molecular Sequence Data, Molecular Structure, Nucleic Acid Synthesis Inhibitors, Nucleosides (chemistry), Nucleosides (pharmacology), Orthomyxoviridae (drug effects), Protease Inhibitors (chemistry), Protease Inhibitors (pharmacology), Reverse Transcriptase Inhibitors (chemistry), Reverse Transcriptase Inhibitors (pharmacology), SARS Virus (drug effects).
- MESH :
- chemical , chemistry : Anti-HIV Agents, Antiviral Agents, HIV Integrase Inhibitors, Nucleosides, Protease Inhibitors, Reverse Transcriptase Inhibitors.
- chemical , pharmacology : Anti-HIV Agents, Antiviral Agents, HIV Integrase Inhibitors, Nucleosides, Protease Inhibitors, Reverse Transcriptase Inhibitors.
- drug effects : HIV-1, HIV-2, Hepatitis Viruses, Herpesviridae, Orthomyxoviridae, SARS Virus.
- Amino Acid Sequence, Animals, Clinical Trials as Topic, Drug Design, Drug Evaluation, Preclinical, Humans, Molecular Sequence Data, Molecular Structure, Nucleic Acid Synthesis Inhibitors.
Abstract
This article summarizes key aspects of progress made during 2004 toward the design, discovery and development of antiviral agents for clinical use. Important developments in the identification, characterization and clinical utility of inhibitors of human immunodeficiency virus; the hepatitis viruses, hepatitis B, hepatitis C; the herpes family of viruses, herpes simplex viruses 1 and 2, varicella zoster virus, Epstein-Barr virus and human cytomegalovirus; the respiratory viruses, influenza, respiratory syncytial virus, human metapneumovirus, picornaviruses, measles and the severe acute respiratory syndrome coronavirus; human papilloma virus; rotavirus; Ebola virus and West Nile virus, are reviewed.
DOI: 10.2174/156800505774912893
PubMed: 16535860
Affiliations:
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Meanwell</name><affiliation wicri:level="2"><nlm:affiliation>Department of Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492, USA. Nicholas.Meanwell@bms.com</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Belema, Makonen" sort="Belema, Makonen" uniqKey="Belema M" first="Makonen" last="Belema">Makonen Belema</name></author><author><name sortKey="Carini, David J" sort="Carini, David J" uniqKey="Carini D" first="David J" last="Carini">David J. Carini</name></author><author><name sortKey="D Andrea, Stanley V" sort="D Andrea, Stanley V" uniqKey="D Andrea S" first="Stanley V" last="D'Andrea">Stanley V. D'Andrea</name></author><author><name sortKey="Kadow, John F" sort="Kadow, John F" uniqKey="Kadow J" first="John F" last="Kadow">John F. Kadow</name></author><author><name sortKey="Krystal, Mark" sort="Krystal, Mark" uniqKey="Krystal M" first="Mark" last="Krystal">Mark Krystal</name></author><author><name sortKey="Naidu, B Narasimhulu" sort="Naidu, B Narasimhulu" uniqKey="Naidu B" first="B Narasimhulu" last="Naidu">B Narasimhulu Naidu</name></author><author><name sortKey="Regueiro Ren, Alicia" sort="Regueiro Ren, Alicia" uniqKey="Regueiro Ren A" first="Alicia" last="Regueiro-Ren">Alicia Regueiro-Ren</name></author><author><name sortKey="Scola, Paul M" sort="Scola, Paul M" uniqKey="Scola P" first="Paul M" last="Scola">Paul M. 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Infectious disorders</title><idno type="ISSN">1568-0053</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Anti-HIV Agents (chemistry)</term><term>Anti-HIV Agents (pharmacology)</term><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (pharmacology)</term><term>Clinical Trials as Topic</term><term>Drug Design</term><term>Drug Evaluation, Preclinical</term><term>HIV Integrase Inhibitors (chemistry)</term><term>HIV Integrase Inhibitors (pharmacology)</term><term>HIV-1 (drug effects)</term><term>HIV-2 (drug effects)</term><term>Hepatitis Viruses (drug effects)</term><term>Herpesviridae (drug effects)</term><term>Humans</term><term>Molecular Sequence Data</term><term>Molecular Structure</term><term>Nucleic Acid Synthesis Inhibitors</term><term>Nucleosides (chemistry)</term><term>Nucleosides (pharmacology)</term><term>Orthomyxoviridae (drug effects)</term><term>Protease Inhibitors (chemistry)</term><term>Protease Inhibitors (pharmacology)</term><term>Reverse Transcriptase Inhibitors (chemistry)</term><term>Reverse Transcriptase Inhibitors (pharmacology)</term><term>SARS Virus (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Agents antiVIH ()</term><term>Agents antiVIH (pharmacologie)</term><term>Animaux</term><term>Antiviraux ()</term><term>Antiviraux (pharmacologie)</term><term>Conception de médicament</term><term>Données de séquences moléculaires</term><term>Essais cliniques comme sujet</term><term>Herpesviridae ()</term><term>Humains</term><term>Inhibiteurs de l'intégrase du VIH ()</term><term>Inhibiteurs de l'intégrase du VIH (pharmacologie)</term><term>Inhibiteurs de la synthèse d'acide nucléique</term><term>Inhibiteurs de la transcriptase inverse ()</term><term>Inhibiteurs de la transcriptase inverse (pharmacologie)</term><term>Inhibiteurs de protéases ()</term><term>Inhibiteurs de protéases (pharmacologie)</term><term>Nucléosides ()</term><term>Nucléosides (pharmacologie)</term><term>Orthomyxoviridae ()</term><term>Structure moléculaire</term><term>Séquence d'acides aminés</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) ()</term><term>VIH-2 (Virus de l'Immunodéficience Humaine de type 2) ()</term><term>Virus de l'hépatite ()</term><term>Virus du SRAS ()</term><term>Évaluation préclinique de médicament</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Anti-HIV Agents</term><term>Antiviral Agents</term><term>HIV Integrase Inhibitors</term><term>Nucleosides</term><term>Protease Inhibitors</term><term>Reverse Transcriptase Inhibitors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-HIV Agents</term><term>Antiviral Agents</term><term>HIV Integrase Inhibitors</term><term>Nucleosides</term><term>Protease Inhibitors</term><term>Reverse Transcriptase Inhibitors</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>HIV-1</term><term>HIV-2</term><term>Hepatitis Viruses</term><term>Herpesviridae</term><term>Orthomyxoviridae</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Agents antiVIH</term><term>Antiviraux</term><term>Inhibiteurs de l'intégrase du VIH</term><term>Inhibiteurs de la transcriptase inverse</term><term>Inhibiteurs de protéases</term><term>Nucléosides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Clinical Trials as Topic</term><term>Drug Design</term><term>Drug Evaluation, Preclinical</term><term>Humans</term><term>Molecular Sequence Data</term><term>Molecular Structure</term><term>Nucleic Acid Synthesis Inhibitors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Agents antiVIH</term><term>Animaux</term><term>Antiviraux</term><term>Conception de médicament</term><term>Données de séquences moléculaires</term><term>Essais cliniques comme sujet</term><term>Herpesviridae</term><term>Humains</term><term>Inhibiteurs de l'intégrase du VIH</term><term>Inhibiteurs de la synthèse d'acide nucléique</term><term>Inhibiteurs de la transcriptase inverse</term><term>Inhibiteurs de protéases</term><term>Nucléosides</term><term>Orthomyxoviridae</term><term>Structure moléculaire</term><term>Séquence d'acides aminés</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term><term>VIH-2 (Virus de l'Immunodéficience Humaine de type 2)</term><term>Virus de l'hépatite</term><term>Virus du SRAS</term><term>Évaluation préclinique de médicament</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This article summarizes key aspects of progress made during 2004 toward the design, discovery and development of antiviral agents for clinical use. Important developments in the identification, characterization and clinical utility of inhibitors of human immunodeficiency virus; the hepatitis viruses, hepatitis B, hepatitis C; the herpes family of viruses, herpes simplex viruses 1 and 2, varicella zoster virus, Epstein-Barr virus and human cytomegalovirus; the respiratory viruses, influenza, respiratory syncytial virus, human metapneumovirus, picornaviruses, measles and the severe acute respiratory syndrome coronavirus; human papilloma virus; rotavirus; Ebola virus and West Nile virus, are reviewed.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Connecticut</li></region></list><tree><noCountry><name sortKey="Belema, Makonen" sort="Belema, Makonen" uniqKey="Belema M" first="Makonen" last="Belema">Makonen Belema</name><name sortKey="Carini, David J" sort="Carini, David J" uniqKey="Carini D" first="David J" last="Carini">David J. Carini</name><name sortKey="D Andrea, Stanley V" sort="D Andrea, Stanley V" uniqKey="D Andrea S" first="Stanley V" last="D'Andrea">Stanley V. D'Andrea</name><name sortKey="Kadow, John F" sort="Kadow, John F" uniqKey="Kadow J" first="John F" last="Kadow">John F. Kadow</name><name sortKey="Krystal, Mark" sort="Krystal, Mark" uniqKey="Krystal M" first="Mark" last="Krystal">Mark Krystal</name><name sortKey="Naidu, B Narasimhulu" sort="Naidu, B Narasimhulu" uniqKey="Naidu B" first="B Narasimhulu" last="Naidu">B Narasimhulu Naidu</name><name sortKey="Regueiro Ren, Alicia" sort="Regueiro Ren, Alicia" uniqKey="Regueiro Ren A" first="Alicia" last="Regueiro-Ren">Alicia Regueiro-Ren</name><name sortKey="Scola, Paul M" sort="Scola, Paul M" uniqKey="Scola P" first="Paul M" last="Scola">Paul M. Scola</name><name sortKey="Sit, Sing Yuen" sort="Sit, Sing Yuen" uniqKey="Sit S" first="Sing-Yuen" last="Sit">Sing-Yuen Sit</name><name sortKey="Walker, Michael A" sort="Walker, Michael A" uniqKey="Walker M" first="Michael A" last="Walker">Michael A. Walker</name><name sortKey="Wang, Tao" sort="Wang, Tao" uniqKey="Wang T" first="Tao" last="Wang">Tao Wang</name><name sortKey="Yeung, Kap Sun" sort="Yeung, Kap Sun" uniqKey="Yeung K" first="Kap-Sun" last="Yeung">Kap-Sun Yeung</name></noCountry><country name="États-Unis"><region name="Connecticut"><name sortKey="Meanwell, Nicholas A" sort="Meanwell, Nicholas A" uniqKey="Meanwell N" first="Nicholas A" last="Meanwell">Nicholas A. Meanwell</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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